Comment on article “The Lung in Aerotoxic Syndrome-El pulmón en el síndrome aerotóxico”
May 11, 2022
“The Lung in Aerotoxic Syndrome-El pulmón en el síndrome aerotóxico” published April 2022, a comment to the authors by Bearnairdine Beaumont and Trudie Dadd
Good day
We have had the opportunity to read your latest article “The Lung in Aerotoxic Syndrome-El pulmón en el síndrome aerotóxico” and wish to comment on the briefly mentioned MCS /Multiple Chemical Sensitivity.
Side note: First we thought that the headline of the article must be wrong, due to the very technical introduction.
I (BB) am a diagnosed MCS case myself (with a disability degree of 52% acknowledged legally in 1997) as some of you know and have been researching the subject “chemical poisoning, MCS, AS” since. The then diagnosing doctors came to the conclusion via the substances found in laboratory analysis' following the exposure to fume events and long-term low-level exposure to bleed air and the on-board/in-flight insecticide spraying.
As pleased as we are that you, at last, mentioned a connection between AS and MCS, we are surprised to find only a small mention of this and no references in the added list for people to refer to.
There are two examples below regarding exposure to organophosphates and petrochemicals and MCS - (further down more examples):
http://www.oprus2001.co.uk/fullertonops.pdf
https://journals.sagepub.com/doi/pdf/10.1080/109158199225116
Since your article is limited to lungs/respiratory symptoms, we will focus on that also - allow us to add to the mentioned “coughing” as follows:
· Bronchial hyper reactivity/ wheezing leading to
· breathing problems (aka „allergic“ bronchial asthma) which obviously can cause
coughing
· swelling of the respiratory mucous membranes*, throat, tongue (sensation of
choking = again breathing problems). *
*Note for consideration: Vocal chord paralysis/intermittent paralysis following exposure is another symptom of AS not mentioned and also appears as MCS symptom. The impossibility to swallow restricts breathing.
The above are the same symptoms you mention in paragraph 6) for AS.
(Quote): “Some patients may also fulfill the criteria of multiple chemical sensitivity (MCS), another long-term possible respiratory presentation of AS.”
Repeated exposure with chronic symptoms persisting can be labeled “MCS” as a result of poisoning. The basis of MCS is always „poisoning“. MCS is not restricted to the lungs but affects "multi-organ", something we also see in what has been coined as: AS – Aerotoxic Syndrome.
A major paper on Multiple Chemical Sensitivity by Professor Martin L. Pall who is a top expert concerning MCS was published on Oct. 23 2009 (chapter 92) in the prestigious reference work for professional toxicologists, General and Applied Toxicology, 3rd Edition (2009, John Wiley & Sons).
To quote Professor Martin Pall:
„We have a detailed and generally well-supported mechanism for MCS. This mechanism explains both the high-level chemical sensitivity that is the most characteristic symptom of MCS, as well as many other symptoms and signs of this disease, can be generated. This mechanism is centred on a biochemical vicious cycle, known as the NO/ONOO-cycle, which interacts with other mechanisms previously implicated in MCS, notably neural sensitization and neurogenic inflammation. These act locally, in various tissues of the body, to generate local sensitivity in regions of the brain and peripheral tissues including lungs, upper respiratory tract and regions of the skin and the GI tract. Because of this local nature, different MCS patients differ from one another in their sensitivity symptoms, because the tissues impacted differ from one patient to another. In addition to the evidence discussed above, this general mechanism is supported by various physiological changes found in MCS and related illnesses, studies of MCS animal models, objectively measurable responses of MCS patients to low-level chemical exposure and by therapeutic responses reported for MCS and related illnesses.” (source)
https://www.mcs-aware.org/images/Martin_Pall_End_of_Controversy.pdf
https://youtu.be/6A7r1gemjto
Some Pall papers:
Since there is no ICD code/classification for AS yet, referencing the codes used for MCS (F45* or T78.4 and side-codes) while adding the various suggested "aircraft" related injury ICD codes which BB sent in the past should be helpful, and we suggest it to also be a discussion point in future articles (and the Medical Protocol) you may be planning.
*”The ICD code F45 or T78.4 (see adjacent codes) is used to code Multiple chemical sensitivity. Multiple chemical sensitivity (MCS) or idiopathic environmental intolerances (IEI) is a chronic medical condition and syndrome characterized by symptoms that the affected person attributes to low-level chemical exposures to commonly used chemicals. Commonly attributed substances include scented products, pesticides, plastics, synthetic fabrics, smoke, petroleum products, and paint fumes. Commonly reported symptoms also include nausea, dizziness, and inflammation of the skin, joints, gastrointestinal tract and airway...” (source: WHO ICD code F45)
We hope the above may be of some help. (P.S. just in: https://www.bbc.com/news/health-61398886 )
Regards
“The Lung in Aerotoxic Syndrome-El pulmón en el síndrome aerotóxico” published April 2022, a comment to the authors by Bearnairdine Beaumont and Trudie Dadd
Good day
We have had the opportunity to read your latest article “The Lung in Aerotoxic Syndrome-El pulmón en el síndrome aerotóxico” and wish to comment on the briefly mentioned MCS /Multiple Chemical Sensitivity.
Side note: First we thought that the headline of the article must be wrong, due to the very technical introduction.
I (BB) am a diagnosed MCS case myself (with a disability degree of 52% acknowledged legally in 1997) as some of you know and have been researching the subject “chemical poisoning, MCS, AS” since. The then diagnosing doctors came to the conclusion via the substances found in laboratory analysis' following the exposure to fume events and long-term low-level exposure to bleed air and the on-board/in-flight insecticide spraying.
As pleased as we are that you, at last, mentioned a connection between AS and MCS, we are surprised to find only a small mention of this and no references in the added list for people to refer to.
There are two examples below regarding exposure to organophosphates and petrochemicals and MCS - (further down more examples):
http://www.oprus2001.co.uk/fullertonops.pdf
https://journals.sagepub.com/doi/pdf/10.1080/109158199225116
Since your article is limited to lungs/respiratory symptoms, we will focus on that also - allow us to add to the mentioned “coughing” as follows:
· Bronchial hyper reactivity/ wheezing leading to
· breathing problems (aka „allergic“ bronchial asthma) which obviously can cause
coughing
· swelling of the respiratory mucous membranes*, throat, tongue (sensation of
choking = again breathing problems). *
*Note for consideration: Vocal chord paralysis/intermittent paralysis following exposure is another symptom of AS not mentioned and also appears as MCS symptom. The impossibility to swallow restricts breathing.
The above are the same symptoms you mention in paragraph 6) for AS.
(Quote): “Some patients may also fulfill the criteria of multiple chemical sensitivity (MCS), another long-term possible respiratory presentation of AS.”
Repeated exposure with chronic symptoms persisting can be labeled “MCS” as a result of poisoning. The basis of MCS is always „poisoning“. MCS is not restricted to the lungs but affects "multi-organ", something we also see in what has been coined as: AS – Aerotoxic Syndrome.
A major paper on Multiple Chemical Sensitivity by Professor Martin L. Pall who is a top expert concerning MCS was published on Oct. 23 2009 (chapter 92) in the prestigious reference work for professional toxicologists, General and Applied Toxicology, 3rd Edition (2009, John Wiley & Sons).
To quote Professor Martin Pall:
„We have a detailed and generally well-supported mechanism for MCS. This mechanism explains both the high-level chemical sensitivity that is the most characteristic symptom of MCS, as well as many other symptoms and signs of this disease, can be generated. This mechanism is centred on a biochemical vicious cycle, known as the NO/ONOO-cycle, which interacts with other mechanisms previously implicated in MCS, notably neural sensitization and neurogenic inflammation. These act locally, in various tissues of the body, to generate local sensitivity in regions of the brain and peripheral tissues including lungs, upper respiratory tract and regions of the skin and the GI tract. Because of this local nature, different MCS patients differ from one another in their sensitivity symptoms, because the tissues impacted differ from one patient to another. In addition to the evidence discussed above, this general mechanism is supported by various physiological changes found in MCS and related illnesses, studies of MCS animal models, objectively measurable responses of MCS patients to low-level chemical exposure and by therapeutic responses reported for MCS and related illnesses.” (source)
https://www.mcs-aware.org/images/Martin_Pall_End_of_Controversy.pdf
https://youtu.be/6A7r1gemjto
Some Pall papers:
- Pall M.L. (2007) Explaining “Unexplained Illnesses”: Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, Gulf War Syndrome and Others. Harrington Park (Haworth) Press, New York. Purchase from Nutri-Link
- Pall M.L. (2000) Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome. Med Hypotheses 54,115-125. View Abstract
- Pall M.L. (2001) Common aetiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. Med Hypotheses 57,139-145. View Abstract
- Pall M.L. (2002) NMDA sensitization and stimulation by peroxynitrite, nitric oxide and organic solvents at the mechanism of chemical sensitivity in multiple chemical sensitivity. FASEB J 16,1407-1417. View Abstract
- Pall M.L. (2008) Post-radiation syndrome as a NO/ONOO(-) cycle, chronic fatigue syndrome-like disease. Med Hypotheses 71: 537-541. View Abstract
- Pall M.L. (2006) The NO/ONOO- cycle as the cause of fibromyalgia and related illnesses: Etiology, explanation and effective therapy. In: New Research in Fibromyalgia, John A. Pederson, Ed., pp 39-59, Nova Science Publishers, Inc., Hauppauge, NY.
- Pall M.L., Anderson J.H. (2004) The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensitivity. Arch Environ Health 59,363-372. View Abstract
- Pall M.L., Satterlee J.D. (2001) Elevated nitric oxide/peroxynitrite mechanism for the common aetiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder. Ann N Y Acad Sci 933,323-329. View Abstract
- Pall M.L. (2009) The NO/ONOO- cycle mechanism as the cause chronic fatigue syndrome/myalgic encephalomyelitis. In: New Research in Chronic Fatigue Syndrome, John A. Pederson, Ed., Nova Science Publishers, Inc., Hauppauge, NY, in Press. View Abstract
- Pall M.L. (2009) Multiple chemical sensitivity: toxicological questions and mechanisms. Wiley & Sons, New York, in press.
Since there is no ICD code/classification for AS yet, referencing the codes used for MCS (F45* or T78.4 and side-codes) while adding the various suggested "aircraft" related injury ICD codes which BB sent in the past should be helpful, and we suggest it to also be a discussion point in future articles (and the Medical Protocol) you may be planning.
*”The ICD code F45 or T78.4 (see adjacent codes) is used to code Multiple chemical sensitivity. Multiple chemical sensitivity (MCS) or idiopathic environmental intolerances (IEI) is a chronic medical condition and syndrome characterized by symptoms that the affected person attributes to low-level chemical exposures to commonly used chemicals. Commonly attributed substances include scented products, pesticides, plastics, synthetic fabrics, smoke, petroleum products, and paint fumes. Commonly reported symptoms also include nausea, dizziness, and inflammation of the skin, joints, gastrointestinal tract and airway...” (source: WHO ICD code F45)
We hope the above may be of some help. (P.S. just in: https://www.bbc.com/news/health-61398886 )
Regards
