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Comment on article  “The Lung in Aerotoxic Syndrome-El pulmón en el síndrome aerotóxico”
May 11, 2022
 
 
“The Lung in Aerotoxic Syndrome-El pulmón en el síndrome aerotóxico” published April 2022, a comment to the authors by Bearnairdine Beaumont and Trudie Dadd

Good day 
 
We have had the opportunity to read your latest article “The Lung in Aerotoxic Syndrome-El pulmón en el síndrome aerotóxico” and wish to comment on the briefly mentioned MCS /Multiple Chemical Sensitivity.
 
Side note: First we thought that the headline of the article must be wrong, due to the very technical introduction.

I (BB) am a diagnosed MCS case myself (with a disability degree of 52% acknowledged legally in 1997) as some of you know and have been researching the subject “chemical poisoning, MCS, AS” since. The then diagnosing doctors came to the conclusion via the substances found in laboratory analysis' following the exposure to fume events and long-term low-level exposure to bleed air and the on-board/in-flight insecticide spraying.

As pleased as we are that you, at last, mentioned a connection between AS and MCS, we are surprised to find only a small mention of this and no references in the added list for people to refer to.
 
There are two examples below regarding exposure to organophosphates and petrochemicals and MCS - (further down more examples):
 
http://www.oprus2001.co.uk/fullertonops.pdf
https://journals.sagepub.com/doi/pdf/10.1080/109158199225116
 
Since your article is limited to lungs/respiratory symptoms, we will focus on that also - allow us to add to the mentioned “coughing” as follows:
 
· Bronchial hyper reactivity/ wheezing leading to
· breathing problems (aka „allergic“ bronchial asthma) which obviously can cause   
  coughing
· swelling of the respiratory mucous membranes*, throat, tongue (sensation of 
  choking = again breathing problems). *

*Note for consideration: Vocal chord paralysis/intermittent paralysis following exposure is another symptom of AS not mentioned and also appears as MCS symptom. The impossibility to swallow restricts breathing. 
 
The above are the same symptoms you mention in paragraph 6) for AS.
 
(Quote): “Some patients may also fulfill the criteria of multiple chemical sensitivity (MCS), another long-term possible respiratory presentation of AS.”
 
Repeated exposure with chronic symptoms persisting can be labeled “MCS” as a result of poisoning. The basis of MCS is always „poisoning“. MCS is not restricted to the lungs but affects "multi-organ", something we also see in what has been coined as: AS – Aerotoxic Syndrome.
 
A major paper on Multiple Chemical Sensitivity by Professor Martin L. Pall who is a top expert concerning MCS was published on Oct. 23 2009 (chapter 92) in the prestigious reference work for professional toxicologists, General and Applied Toxicology, 3rd Edition (2009, John Wiley & Sons).

To quote Professor Martin Pall:
 
 „We have a detailed and generally well-supported mechanism for MCS. This mechanism explains both the high-level chemical sensitivity that is the most characteristic symptom of MCS, as well as many other symptoms and signs of this disease, can be generated. This mechanism is centred on a biochemical vicious cycle, known as the NO/ONOO-cycle, which interacts with other mechanisms previously implicated in MCS, notably neural sensitization and neurogenic inflammation. These act locally, in various tissues of the body, to generate local sensitivity in regions of the brain and peripheral tissues including lungs, upper respiratory tract and regions of the skin and the GI tract. Because of this local nature, different MCS patients differ from one another in their sensitivity symptoms, because the tissues impacted differ from one patient to another. In addition to the evidence discussed above, this general mechanism is supported by various physiological changes found in MCS and related illnesses, studies of MCS animal models, objectively measurable responses of MCS patients to low-level chemical exposure and by therapeutic responses reported for MCS and related illnesses.” (source)
 
https://www.mcs-aware.org/images/Martin_Pall_End_of_Controversy.pdf
https://youtu.be/6A7r1gemjto
 
Some Pall papers:
  1. Pall M.L. (2007) Explaining “Unexplained Illnesses”: Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, Gulf War Syndrome and Others. Harrington Park (Haworth) Press, New York. Purchase from Nutri-Link
  2. Pall M.L. (2000) Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome. Med Hypotheses 54,115-125. View Abstract
  3. Pall M.L. (2001) Common aetiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. Med Hypotheses 57,139-145. View Abstract
  4. Pall M.L. (2002) NMDA sensitization and stimulation by peroxynitrite, nitric oxide and organic solvents at the mechanism of chemical sensitivity in multiple chemical sensitivity. FASEB J 16,1407-1417. View Abstract
  5. Pall M.L. (2008) Post-radiation syndrome as a NO/ONOO(-) cycle, chronic fatigue syndrome-like disease. Med Hypotheses 71: 537-541. View Abstract
  6. Pall M.L. (2006) The NO/ONOO- cycle as the cause of fibromyalgia and related illnesses: Etiology, explanation and effective therapy. In: New Research in Fibromyalgia, John A. Pederson, Ed., pp 39-59, Nova Science Publishers, Inc., Hauppauge, NY.
  7. Pall M.L., Anderson J.H. (2004) The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensitivity. Arch Environ Health 59,363-372. View Abstract
  8. Pall M.L., Satterlee J.D. (2001) Elevated nitric oxide/peroxynitrite mechanism for the common aetiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder. Ann N Y Acad Sci 933,323-329. View Abstract
  9. Pall M.L. (2009) The NO/ONOO- cycle mechanism as the cause chronic fatigue syndrome/myalgic encephalomyelitis. In: New Research in Chronic Fatigue Syndrome, John A. Pederson, Ed., Nova Science Publishers, Inc., Hauppauge, NY, in Press. View Abstract
  10. Pall M.L. (2009) Multiple chemical sensitivity: toxicological questions and mechanisms.  Wiley & Sons, New York, in press.
 
Since there is no ICD code/classification for AS yet, referencing the codes used for MCS (F45* or T78.4 and side-codes) while adding the various suggested "aircraft" related injury ICD codes which BB sent in the past should be helpful, and we suggest it to also be a discussion point in future articles (and the Medical Protocol) you may be planning.
 
 *”The ICD code F45 or T78.4 (see adjacent codes) is used to code Multiple chemical sensitivity. Multiple chemical sensitivity (MCS) or idiopathic environmental intolerances (IEI) is a chronic medical condition and syndrome characterized by symptoms that the affected person attributes to low-level chemical exposures to commonly used chemicals. Commonly attributed substances include scented products, pesticides, plastics, synthetic fabrics, smoke, petroleum products, and paint fumes. Commonly reported symptoms also include nausea, dizziness, and inflammation of the skin, joints, gastrointestinal tract and airway...” (source: WHO ICD code F45)
 
We hope the above may be of some help. (P.S. just in: https://www.bbc.com/news/health-61398886 )

Regards


 
 
 
 


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Unfortunately we are not able to provide personal advice to individuals on diagnosis, treatment and professionals, and/or legal matters. However, you will find all necessary information within these pages. Thank you for your understanding and we hope that the materials on this website will help answer your questions.

​Disclaimer: I am not a medical doctor but a concerned citizen collating research. The provided information should be double checked by everyone according to their personal circumstances before embarking on any treatment in consultation with their personal doctor who knows about the discussed subject and their medical history. Please make sure to present the three downloadable documents HERE  for your doctor's information. This is an effort to share what I have learnt by reading many scientific and medical journals on this subject.


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  • HOME
    • SPANISH
    • Who's who?
    • Report an Incident
  • What are Fume Events?
    • Fume Events? Aerotoxic Syndrome? >
      • Aerotoxic Syndrome Advice
    • Medical INFO
    • Why ICD-Classification?
    • Science
    • Flying while pregnant
  • Unfiltered - contents of fumes
  • Evidence
    • Time Line
    • Evidence in Documentaries
    • Court Cases >
      • ICC The Hague
      • The Hague
    • Testimonies
    • FAQ's
  • CREW mask info
    • Flyer's Friend®
  • Chemicals With Wings
    • Research Articles
  • Passenger Videos
  • Filtration Expert Articles
    • Contaminated air in airliner cabins, A summary but comprehensive presentation by John M. Lind CPCU ARM
    • ASHRAE Introduction to Passenger Aircraft Cabin Air /Summary R. Schuetz
    • Aeronautical Engineering Prof. Dr.-Ing Dieter Scholz
    • Flying despite Corona? Markus Steinhausen
    • Airbus' Cabin Air Explanations during the Corona Pandemic Prof. Dr D. Scholz
    • Airborne COVID-19 Decontamination Reinhard Schuetz P. Eng.
    • Airline CEO's Obsession... Bearnairdine Beaumont
    • Filtration Efficiency Claims: Misleading? Reinhard Schuetz P. Eng.
    • HEPA Technology Tested
    • Forgotten Pollution: Cabin Air Quality Rein A. Roos PhD
  • PETITION
    • Petition en Français
    • Petition in English
    • Petition auf Deutsch
    • Petition en Español
    • Petition in het Nederlands
  • MEDICAL HEALTH CONCERNS at Altitude, Fumes & Vaccinations